Abstract
The development of efficient methods for C(sp(3))-C(sp(3)) bond formation remains a longstanding challenge in synthetic chemistry, especially in palladium catalysis employing sterically bulky electrophiles. In this study, we present a novel approach for achieving C(sp(3))-C(sp(3)) cross-coupling via photoinduced palladium catalysis, employing cyclopropanols as masked C(sp(3))-nucleophiles. Leveraging the unique reactivity of photoexcited palladium, this protocol enables radical-mediated C(sp(3))-C(sp(3)) coupling across a broad range of substrates including sterically hindered and functionally diverse alkyl halides under mild conditions. This method significantly expands the extent of palladium-catalysed cross-coupling for bond construction between sp(3)-hybridized carbon units, providing streamlined access to structurally complex C(sp(3))-rich frameworks that are crucial for medicinal chemistry.