Equilibrating parent aminomercaptocarbene and CO(2) with 2-amino-2-thioxoacetic acid via heavy-atom quantum tunneling

通过重原子量子隧穿效应使母体氨基巯基卡宾和CO(2)与2-氨基-2-硫代乙酸达到平衡

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Abstract

The search for methods to bind CO(2) and use it synthetically as a C(1)-building block under mild conditions is an ongoing endeavor of great urgency. The formation of heterocyclic carbene-carbon dioxide adducts occurs rapidly when the carbene is generated in solution in the presence of CO(2). Here we demonstrate the reversible formation of a complex of the hitherto unreported aminomercaptocarbene (H(2)N-C̈-SH) with CO(2) isolated in solid argon by photolysis of 2-amino-2-thioxoacetic acid. Remarkably, the complex disappears in the dark as deduced by time-dependent matrix infrared measurements, and equilibrates back to the covalently bound starting material. This kinetically excluded process below ca. 8 K is made possible through heavy-atom quantum mechanical tunneling, as also evident from density functional theory and ab initio computations at the CCSD(T)/cc-pVTZ level of theory. Our results provide insight into CO(2) activation using a carbene and emphasize the role of quantum mechanical tunneling in organic processes, even involving heavy atoms.

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