NR4A1 suppresses pyroptosis by transcriptionally inhibiting NLRP3 and IL-1β and co-localizing with NLRP3 in trans-Golgi to alleviate pathogenic bacteria-induced colitis

NR4A1通过转录抑制NLRP3和IL-1β，并与NLRP3在反式高尔基体中共定位，从而抑制细胞焦亡，减轻病原菌引起的结肠炎。