Abstract
PURPOSE: Both of extracellular extravascular volume (EEV) and extracellular volume fraction (ECV) were proposed to quantify enlargement of myocardial interstitial space due to myocardium loss or fibrosis. The study aimed to investigate the feasibility of using EEV derived from myocardial computed tomography (CT) perfusion imaging (VPCT) and extracellular volume quantification with single-energy subtraction CT (ECV(- SECT)) for quantifying myocardial fibrosis. METHODS: In this study, 17 patients with suspected and known coronary artery disease underwent examination using a dual-source CT scanner. The EEV(- VPCT) was derived from dynamic whole-heart myocardial perfusion imaging, and the ECV(_SECT) was calculated from late-enhanced images 5 min after bolus contrast injection by subtracting the noncontrast baseline. The late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging was used as a reference. RESULTS: In total, 11 patients and 73 segments exhibited positivity for LGE on CMR imaging. These were classified into three groups according to the segments: fibrotic segments (group I, n = 73), nonfibrotic segments in LGE-positive patients (group II, n = 103), and segments in LGE-negative patients (group III, n = 80). ECV(- SECT), EEV(- VPCT), myocardial blood flow (MBF), and myocardial blood volume (MBV) significantly differed among these groups (all P < 0.05). ECV(- SECT) was significantly higher and EEV(- VPCT), MBF, and MBV were significantly lower in fibrotic myocardial segments than in nonfibrotic ones (all P < 0.01). ECV(- SECT) and EEV(- VPCT) independently affected myocardial fibrosis. There was no significant correlation between ECV(- SECT) and EEV(- VPCT). The capability of EEV(- VPCT) to diagnose myocardial fibrosis was equivalent to that of ECV(- SECT) (area under the curve: 0.798 vs. 0.806, P = 0.844). ECV(- SECT) of > 41.2% and EEV(- VPCT) of < 10.3% indicated myocardial fibrosis. CONCLUSIONS: EEV(- VPCT) is actually first-pass distribution volume that can feasibly be used to quantify myocardial fibrosis. Furthermore, the diagnostic efficacy of EEV(- VPCT) is comparable to that of ECV(- SECT).