Quantitative analysis of 2-methoxy-3,5-dimethylpyrazine as an earthy-musty off-odor compound in drinking water using HS-SPME-GC-MS

利用顶空固相微萃取-气相色谱-质谱联用技术对饮用水中2-甲氧基-3,5-二甲基吡嗪(一种土腥味异味化合物)进行定量分析

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Abstract

The presence of off-odors can influence the overall taste of drinking water, with earthy-musty odors often being perceived as indicator of stale or poor-quality water. Recently, earthy-musty off-odor from drinking water was reported in some part of South Korea. The earthy-musty off-odor compound was identified as 2-methoxy-3,5-dimethylpyrazine (2-MDMP) through simultaneous steam distillation and solvent extraction-gas chromatography-mass spectrometry (SDE-GC-MS) and GC-olfactometry (GC-O). For quantitative analysis of 2-MDMP in drinking water, headspace-solid phase microextraction-GC-MS (HS-SPME-GC-MS) method was optimized in terms of salt concentration, absorption temperature, and absorption time. Validation of the method confirmed its reliability, with linearity (R(2) = 0.9998) at working range of 2.5-500 ng/mL, limit of detection (0.83 ng/mL), and limit of quantification (2.5 ng/mL). The method also demonstrated that precision and accuracy were satisfactory. Using validated HS-SPME-GC-MS, the concentration of 2-MDMP in drinking water exhibiting earthy-musty off-odor was quantified to 77.2 ng/mL.

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