Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential

Emerin 失调将核形状不稳定性与转移潜能联系起来

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作者:Mariana Reis-Sobreiro, Jie-Fu Chen, Tatiana Novitskaya, Sungyong You, Samantha Morley, Kenneth Steadman, Navjot Kaur Gill, Adel Eskaros, Mirja Rotinen, Chia-Yi Chu, Leland W K Chung, Hisashi Tanaka, Wei Yang, Beatrice S Knudsen, Hsian-Rong Tseng, Amy C Rowat, Edwin M Posadas, Andries Zijlstra, Dolor

Significance

This study identifies a novel mechanism integrating the control of nuclear structure with the metastatic phenotype, and our inclusion of two types of human specimens (cancer tissues and circulating tumor cells) demonstrates direct relevance to human cancer.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/21/6086/F1.large.jpg Cancer Res; 78(21); 6086-97. ©2018 AACR.

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