Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate

怀孕非人灵长类动物皮下接种寨卡病毒后胎儿脑部损伤

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作者：Adams Waldorf,Kristina M,Stencel-Baerenwald,Jennifer E,Kapur,Raj P,Studholme,Colin,Boldenow,Erica,Vornhagen,Jay,Baldessari,Audrey,Dighe,Manjiri K,Thiel,Jeff,Merillat,Sean,Armistead,Blair,Tisoncik-Go,Jennifer,Green,Richard R,Davis,Michael A,Dewey,Elyse C,Fairgrieve,Marian R,Gatenby,J Christopher,Richards,Todd,Garden,Gwenn A,Diamond,Michael S,Juul,Sandra E,Grant,Richard F,Kuller,LaRene,Shaw,Dennis W W,Ogle,Jason,Gough,G Michael,Lee,Wonsok,English,Chris,Hevner,Robert F,Dobyns,William B,Gale,Michael Jr,Rajagopal,Lakshmi
期刊：Nature Medicine影响因子：50.000
时间：2016起止号：2016 Nov;22(11):1256-1259
doi：10.1038/nm.4193研究方向： 微生物学、神经科学

Abstract

We describe the development of fetal brain lesions after Zika virus (ZIKV) inoculation in a pregnant pigtail macaque. Periventricular lesions developed within 10 d and evolved asymmetrically in the occipital-parietal lobes. Fetal autopsy revealed ZIKV in the brain and significant cerebral white matter hypoplasia, periventricular white matter gliosis, and axonal and ependymal injury. Our observation of ZIKV-associated fetal brain lesions in a nonhuman primate provides a model for therapeutic evaluation.

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