Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer's disease with cotton wool plaques due to a novel presenilin1 G417S mutation

由一种新的早老素1 G417S突变引起的阿尔茨海默病，表现为青年起病、进展非常缓慢的认知功能下降，伴有痉挛性截瘫和棉絮状斑块。