Drug-Loaded Silver Nanoparticles-A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

载药银纳米粒子——一种用于治疗炎症性肠病的美贝维林前体的输送工具

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作者:Mina Todorova, Miglena Milusheva, Lidia Kaynarova, Deyana Georgieva, Vassil Delchev, Stanislava Simeonova, Bissera Pilicheva, Stoyanka Nikolova

Methods

A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles.

Results

The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary.

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