Abstract
Myocardial T(1)-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T(1)-mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T(1)-mapping method was modified to enable imaging during systole. Phantom measurements were used to evaluate the insensitivity of systolic T(1)-mapping towards heart-rate variability. In-vivo feasibility and accuracy were demonstrated in ten healthy volunteers with native and post-contrast T(1)-mappping during systole and diastole. To show benefits in the presence of RR-variability, six arrhythmic patients underwent native T(1)-mapping. Resulting systolic SAPPHIRE T(1)-values showed no dependence on arrhythmia in phantom (CoV < 1%). In-vivo, significantly lower T(1) (1563 ± 56 ms, precision: 84.8 ms) and ECV-values (0.20 ± 0.03) than during diastole (T(1) = 1580 ± 62 ms, p = 0.0124; precision: 60.2 ms, p = 0.03; ECV = 0.21 ± 0.03, p = 0.0098) were measured, with a strong correlation of systolic and diastolic T(1) (r = 0.89). In patients, mis-triggering-induced motion caused significant imaging artifacts in diastolic T(1)-maps, whereas systolic T(1)-maps displayed resilience to arrythmia. In conclusion, the proposed method enables saturation-recovery T(1)-mapping during systole, providing increased robustness against partial-voluming compared to diastolic imaging, for the benefit of T(1)-measurements in arrhythmic patients.