Molecular analysis of serum and bronchoalveolar lavage in a mouse model of influenza reveals markers of disease severity that can be clinically useful in humans
对小鼠流感模型中的血清和支气管肺泡灌洗液进行分子分析，揭示了可用于人类临床的疾病严重程度标志物
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作者：Yadunanda Kumar, Cui Liang, Gino V Limmon, Li Liang, Bevin P Engelward, Eng Eong Ooi, Jianzhu Chen, Steven R Tannenbaum
| 期刊： | PLoS One | 影响因子： | 2.900 |
| 时间： | 2014 | 起止号： | 2014 Feb 5;9(2):e86912. |
| doi： | 10.1371/journal.pone.0086912 | 种属： | Mouse |
| 方法学： | FCM、IF、IHC-P、WB | 研究方向： | 免疫 |
| 疾病类型： | 流感 | |
Background
Management of influenza, a major contributor to the worldwide disease burden, is complicated by lack of reliable
Significance
The findings from this study provide a molecular description of disease progression in a mouse model of influenza and demonstrate its potential for translation into a novel class of markers for measurement of acute lung injury and improved case management.
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