Successful Pregnancies Following Liver Transplantation for Wilson's Disease: A Case Report and Literature Review

威尔逊病肝移植术后成功妊娠:病例报告及文献综述

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Abstract

Pregnancy in women with a history of liver transplantation is considered high risk due to concerns about graft function, immunosuppressive therapy, and maternal-fetal complications. We present the case of a young woman who underwent liver transplantation for fulminant hepatic failure in adolescence and subsequently achieved two successful pregnancies with favorable maternal and neonatal outcomes. Her pregnancies were carefully managed through close collaboration between transplant specialists and obstetricians, with regular monitoring of graft function, immunosuppressive levels, and maternal-fetal well-being. Both deliveries were uneventful, and long-term follow-up revealed stable graft function and healthy children. A review of previously reported cases demonstrates that while risks such as preterm delivery, low birth weight, and hypertensive disorders exist, favorable outcomes are increasingly achievable with meticulous multidisciplinary care. This case highlights the potential for successful pregnancies following liver transplantation and emphasizes the importance of individualized management, patient counseling, and long-term follow-up.

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