Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration

用于周围神经再生的壳聚糖和单壁碳纳米管复合纤维的结构和性能

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作者:Elena N Dresvyanina, Nurjemal A Tagandurdyyeva, Vera V Kodolova-Chukhontseva, Irina P Dobrovol'skaya, Almaz M Kamalov, Yulia A Nashchekina, Alexey V Nashchekin, Alexey G Ivanov, Galina Yu Yukina, Vladimir E Yudin

Abstract

This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber.

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