Abstract
BACKGROUND: Diabetes osteoporosis is a debilitating condition that significantly impacts human health. However, it is often underdiagnosed and not addressed in a timely or appropriate manner. METHODS: Recent studies were reviewed to explore the roles of energy metabolism, sarcopeina, low-grade inflammation and gut microbiota in the development of diabetes osteoporosis. RESULTS: Osteoporosis in diabetic patients differs from primary osteoporosis. Novel biomarkers and risk factors that are biologically, physiologically, and pathologically linked to the development of diabetes osteoporosis are emerging, necessitating a shift in strategies for diagnosis, risk stratification, and prevention of diabetes osteoporosis. CONCLUSIONS: There is an urgent need to approach this disorder from a fresh perspective, initiating a range of basic research and clinical investigations.