Inflammatory cascades driven by tumor necrosis factor-alpha play a major role in the progression of acute liver failure and its neurological complications

Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that

Acute liver failure (ALF) due to ischemic or toxic liver injury is a clinical condition that

These results indicate that systemic sequestration of TNF-α attenuates both peripheral and cerebral inflammation leading to delayed progression of liver disease and HE in mice with ALF due to toxic liver injury. These results suggest that etanercept may provide a novel therapeutic approach for the management of ALF patients awaiting liver transplantation.