Abstract
BACKGROUND: Liver failure is usually associated with the inflammation and oxidation of hepatocytes. Due to their unique properties, graphene and graphene-based nanostructures such as magnetic graphene oxide (MGO) are useful in biomedicine and engineering. In this study, synthesized MGO was used to improve the liver failure induced by carbon tetrachloride (CCl(4)). The hepatoprotective effects of intraperitoneal injection of MGO on the rat model of CCl(4)-induced acute liver failure were investigated. MATERIALS AND METHODS: In order to provide a rat model of acute liver failure, male rats were intraperitoneally injected with 2 ml/kg body weight CCl(4). In the experimental groups, rats received 2 ml/kg CCl(4) and 300 mg/kg MGO body weight simultaneously. Four days after injection, symptoms of acute liver failure appeared. The control, sham, CCl(4), and CCl(4) + MGO groups were compared and analyzed both histologically and biochemically. RESULTS: The results indicated that the MGO injection reduced all CCl(4)-induced liver failure such as necrosis, fibrosis, inflammation, aspartate transaminase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in the experimental groups of the rat model of acute liver failure. CONCLUSION: The hepatoprotective effects of MGO might be due to histopathological suppression and inflammation inhibition in the liver.