Abstract
BACKGROUND: Deep vein thrombosis (DVT) represents a significant and potentially lethal complication in bedridden elderly inpatients, leading to severe disability and mortality. PURPOSE: This study aimed to identify determinants contributing to DVT incidence in elderly patients with concurrent hip fractures and chronic kidney disease (CKD). METHODS: We collected comprehensive data from elderly patients diagnosed with hip fractures and CKD at our hospital between November 2015 and January 2023. Patients were categorized into DVT and non-DVT groups. We conducted detailed demographic, comorbidity, and laboratory analyses using univariate and logistic regression methods. Receiver-operating characteristic (ROC) curves were utilized to establish critical thresholds for predictive variables. RESULTS: The study revealed a 34.4% DVT rate among 180 patients. Univariate analysis identified significant associations between DVT and older age (p = 0.031), elevated white blood cell (WBC) count (p = 0.005), prolonged thrombin time (TT) (p = 0.030), and increased D-dimer levels (p < 0.001). Logistic regression showed that age (p = 0.009, odds ratio [OR] = 1.049), WBC count (p = 0.001, OR = 1.131), and D-dimer levels (p = 0.010, OR = 1.190) were independent predictors of DVT. ROC analysis established critical thresholds: age (73 years), D-dimer (3.3 ng/mL), and WBC count (9.5 × 10^9/μL). CONCLUSIONS: Age, D-dimer, and WBC levels independently predict DVT in elderly patients with hip fractures and CKD. Precise thresholds facilitate personalized DVT risk assessment, enabling early and targeted interventions.