Abstract
The first direct C-H (18)F fluorination reaction of unactivated aliphatic sites using no-carrier-added [(18)F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-(18)F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of (18)F labeled radio tracers.