Abstract
Middle aged women naturally enter menopause, which increases the risk of several metabolic diseases. The objective of this research was to investigate the regulatory effects of bioactive natural product "Superhongmi" rice bran on hyperglycemia, oxidative stress, and bone metabolism. The ovariectomized Sprague-Dawley rats were randomly divided into three dietary groups (n=10): ovariectomized (OVX)-AIN93M diet (OVX-AIN93M) and OVX-AIN93M diet supplemented with either low dose Superhongmi extract (1 g/kg, OVX-LSH) or high dose Superhongmi extract (5 g/kg, OVXHSH). Body weight, activities of glucose regulatory, antioxidant enzymes, and bone metabolism biochemical markers of rats were measured. After eight weeks of feeding, the OVX-AIN93M group showed a significant increase in body weight gain relative to the sham-operated group. Superhongmi extract diet supplementation (OVX-HSH group) significantly suppressed hyperglycemia, oxidative stress, and bone resorption. These findings indicated that OVX-HSH has a potential therapeutic effect on menopause women.