Empirically developed dietary inflammatory potential (EDIP) in patients candidate for coronary artery bypass grafting surgery (CABG): Association with metabolic parameters, dietary antioxidant quality score and dietary phytochemical index

It has been suggested that empirically developed dietary inflammatory potential (EDIP) is a diagnostic tool for assessment of inflammatory potential of diet in prediction of risk factors related to chronic disease. In the current work, we examined the association between EDIP with cardio-metabolic risk factors, dietary antioxidant quality score (DAQs), dietary phytochemical index (DPI) and Mediterranean dietary quality index (MEDQI) in patients candidate for CABG. Materials and

According to our finding, EDIP was associated with obesity, high prevalence of dyslipidemia and cardio-metabolic risk factors. Moreover, EDIP was in an inverse association with dietary antioxidant quality score and dietary phytochemical index. Therefore, EDIP could be assumed as a precise tool for estimating the CVD related risk factors among patients candidate for CABG.

In the current cross-sectional study, the data obtained from Tehran- Heart Center-Coronary Outcome Measurement (THC-COM) study from 454 patients candidate for the CABG were used. Laboratory measurements including hemoglobin (Hb)-A1C, serum lipids, creatinine, blood urea nitrogen (BUN), hematocrit, Lp(a), telomerase activity, serum vitamin D and c-reactive protein (CRP) were measured with commercial laboratory methods. Dietary indices were measured according to the data obtained from with semi-quantitative FFQ.

In the current work, patients in top quintile of EDIP had higher BMI and higher prevalence of hyperlipidemia compared with patients in lowest quintile (BMI: 28.08 ±3.68 vs 26.69 ± 3.67 and hyperlipidemia: 77.8 vs 65.5%; P < 0.05). Moreover, lower EDIP scores were accompanied with higher vitamin E (0.48 vs 0.4) and total dietary antioxidant scores (4.40 VS 4.28), higher dietary phytochemical scores (69.79 vs 58.29) and lower dietary Mediterranean quality scores (P < 0.05 and P < 0.01 respectively). In male patients, being at highest quintiles of EDIP make patients 2-5% more likely to have higher concentrations of serum cholesterol, BUN and Lp (a), and 6 to 8 times more likely to have higher creatinine and 66% more likely to have lower albumin concentrations compared with male patients in lowest quintiles. In female patients, lower HCT, higher creatinine, higher CRP concentrations and higher telomerase activity were also achieved by higher EDIP scores (P < 0.05).