Abstract
N6-methyladenosine(m(6)A) is one of the most abundant modifications of mammalian cellular RNAs. m(6)A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m(6)A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m(6)A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease.