Anticryptosporidial action mechanisms of Launaea spinosa extracts in Cryptosporidium parvum experimentally infected mice in relation to its UHPLC-MS metabolite profile and biochemometric tools

Launaea spinosa 提取物对实验性感染隐孢子虫的小鼠的抗隐孢子虫作用机制及其 UHPLC-MS 代谢物谱和生物化学计量工具

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作者:Mai M Elghonemy, Mohamed G Sharaf El-Din, Dina Aboelsoued, Mohamed F Abdelhameed, Mohamed A El-Saied, Nagwa I Toaleb, Mohamed A Farag, Abdelsamed I Elshamy, Abdelbaset M Elgamal

Background

Cryptosporidium parvum, a leading cause of diarrhea, is responsible for millions of food and waterborne illnesses in humans and animals worldwide. Launaea spinosa (Asteraceae family) is a common herb found in the desert of the Mediterranean region, encompassing the peninsula of Sinai. Traditionally, it has been utilized for managing gastrointestinal issues and inflammation.

Conclusions

This study demonstrated potential anti-cryptosporidial effects of LS extracts, especially LS-BuOH, suggesting its potential for inclusion in future nutraceuticals aimed at C. parvum treatment.

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