Abstract
In this issue of Blood, Cherpokova et al have identified for the first time the important role lipid mediators play in both formation and resolution of clots in deep vein thrombosis (DVT). Their discovery, that Resolvin D4 (RvD4) is a critical specialized proresolving mediator that limits NETosis in the formation of the clot, as well as regulating the rate of clot resolution, identifies a new target for therapeutic intervention and reinforces the important role lipid metabolites play in regulation of blood clot formation under pathologic conditions.