Abstract
The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. The subject of Chapter 779 is Birnavirus VP4 Processing Endopeptidase. Keywords Autoproteolytic proteinase release, birnavirus, α/β fold, multifunctional proteinase, narrow substrate specificity, polyprotein processing, RNA virus, replication control, serine-lysine proteinase, virion formation control.