Abstract
OBJECTIVES: To investigate the dynamic changes in multiple planes and parameters of the aortic root region at different phases of the cardiac cycle in patients with aortic regurgitation (AR) using multi-detector row computed tomography (MDCT). To provide more reference information and research foundation for preoperative MDCT evaluation of patients with aortic regurgitation undergoing Transcatheter Aortic Valve Replacement (TAVR). METHODS: Using MDCT, measurements were taken at the aortic annulus (AA), left ventricular outflow tract (LVOT), and sinotubular junction (STJ) during different phases of the cardiac cycle, including early systole, late systole, early diastole, and late diastole. The analyzed parameters included area, perimeter, diameter derived from area (DA), diameter derived from circumference (DC), long axis, short axis, and average diameter at each phase for each location. The dynamic changes in these parameters were then analyzed. RESULTS: At the AA, the early systolic area, perimeter, DA, DC, and average diameter reached their maximum values, which were significantly greater than those in early diastole (P < 0.05). At the LVOT, the morphological parameters including area, perimeter, DC, DA, and long diameter reached their maximum values in late diastole, with no significant differences compared to early or late systole (P > 0.05). However, significant differences were observed between late diastole and early diastole (P < 0.05).At the STJ, the area, perimeter, DA, DC, long diameter, short diameter, and average diameter reached their maximum values in late systole, but there were no significant differences compared to early systole or early diastole (P > 0.05), while the difference from late diastole was significant (P < 0.05). CONCLUSION: In patients with AR, the measurement parameters of the AA、LVOT and the STJ are critical for the success of TAVR.Preoperative prosthesis selection for TAVR can still be based on MDCT measurements taken during early systole at the AA.