Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells
制造带有荧光示踪剂的聚对苯二甲酸乙二醇酯 (PET) 纳米粒子用于哺乳动物细胞研究
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作者:Leah M Johnson, Jeffrey B Mecham, Sai Archana Krovi, Maria M Moreno Caffaro, Shyam Aravamudhan, Alexander L Kovach, Timothy R Fennell, Ninell P Mortensen
| 期刊: | Nanoscale Advances | 影响因子: | 4.600 |
| 时间: | 2020 | 起止号: | 2020 Dec 15;3(2):339-346. |
| doi: | 10.1039/d0na00888e | 研究方向: | 免疫、细胞生物学 |
| 细胞类型: | 其它细胞 | |
Abstract
Fluorescent nanoparticles (NPs) comprising polyethylene terephthalate (PET) with a hydrodynamic diameter of 158 ± 2 nm were synthesized in a bottom-up approach. Concentration-dependent uptake and cytotoxicity of PET NPs in macrophages are shown. The fabrication of well-characterized NPs, derived from high-commodity polymers, will support future studies to assess effects on biological systems.
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