Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells

制造带有荧光示踪剂的聚对苯二甲酸乙二醇酯 (PET) 纳米粒子用于哺乳动物细胞研究

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作者:Leah M Johnson, Jeffrey B Mecham, Sai Archana Krovi, Maria M Moreno Caffaro, Shyam Aravamudhan, Alexander L Kovach, Timothy R Fennell, Ninell P Mortensen

Abstract

Fluorescent nanoparticles (NPs) comprising polyethylene terephthalate (PET) with a hydrodynamic diameter of 158 ± 2 nm were synthesized in a bottom-up approach. Concentration-dependent uptake and cytotoxicity of PET NPs in macrophages are shown. The fabrication of well-characterized NPs, derived from high-commodity polymers, will support future studies to assess effects on biological systems.

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