Abstract
Correctly ordering a sequence of speech sounds is a crucial aspect of speech production. Although studies have yielded a rich body of data on the neural substrates of visuomotor sequencing and sequence learning, research on brain regions and their functions involving speech sequence production hasn't attracted much attention until recently. Previous functional MRI studies manipulating the complexity of sequences at the phonemic, syllabic, and suprasyllabic levels have revealed a network of motor-related cortical and sub-cortical speech regions. In this study, we directly compared human brain activity measured with functional MRI during processing of a sequence of syllables compared with the same syllables processed individually. Among a network of regions independently identified as being part of the sensorimotor circuits for speech production, only the left posterior inferior frontal gyrus (pars opercularis, lIFG), the supplementary motor area (SMA), and the left inferior parietal lobe (lIPL) responded more during the production of syllable sequences compared to producing the same syllables articulated one at a time.