Generation of an integration-free induced pluripotent stem cell line (CSC-43) from a patient with sporadic Parkinson's disease
从散发性帕金森病患者体内生成无整合诱导性多能干细胞系 (CSC-43)
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作者：Ana Marote, Yuriy Pomeshchik, Stefano Goldwurm, Anna Collin, Nuno J Lamas, Luísa Pinto, António J Salgado, Laurent Roybon
| 期刊： | Stem Cell Research | 影响因子： | 0.800 |
| 时间： | 2018 | 起止号： | 2018 Mar:27:82-85. |
| doi： | 10.1016/j.scr.2018.01.007 | 研究方向： | 发育与干细胞 |
| 疾病类型： | 帕金森 | 细胞类型： | 干细胞 |
Abstract
An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and normal karyotype. This iPSC line can be used to study the mechanisms underlying the development of PD.
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