Generation of a human induced pluripotent stem cell line from a patient diagnosed with schizophrenia carrying a 16p11.2 deletion
从患有 16p11.2 缺失的精神分裂症患者体内生成人类诱导性多能干细胞系
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作者：Deniz A Madencioglu, Karina Kruth, Mallory Shin, Nancy Andreasen, Thomas Wassink, Aislinn Williams
| 期刊： | Stem Cell Research | 影响因子： | 0.800 |
| 时间： | 2022 | 起止号： | 2022 Mar:59:102636. |
| doi： | 10.1016/j.scr.2021.102636 | 研究方向： | 发育与干细胞 |
| 疾病类型： | 精神分裂症 | 细胞类型： | 干细胞 |
Abstract
16p11.2 copy number variations have been associated with neurodevelopmental disorders. Human induced pluripotent stem cells were generated from fibroblasts obtained from a patient diagnosed with schizophrenia with a 16p11.2 deletion. The generated cell line was further validated for its pluripotency and potential to differentiate into the three germ layers.
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