Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

ZNF365 的常见变异与乳腺X线摄影密度和乳腺癌风险均相关。

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作者：Lindström,Sara,Vachon,Celine M,Li,Jingmei,Varghese,Jajini,Thompson,Deborah,Warren,Ruth,Brown,Judith,Leyland,Jean,Audley,Tina,Wareham,Nicholas J,Loos,Ruth J F,Paterson,Andrew D,Rommens,Johanna,Waggott,Darryl,Martin,Lisa J,Scott,Christopher G,Pankratz,V Shane,Hankinson,Susan E,Hazra,Aditi,Hunter,David J,Hopper,John L,Southey,Melissa C,Chanock,Stephen J,Silva,Isabel dos Santos,Liu,JianJun,Eriksson,Louise,Couch,Fergus J,Stone,Jennifer,Apicella,Carmel,Czene,Kamila,Kraft,Peter,Hall,Per,Easton,Douglas F,Boyd,Norman F,Tamimi,Rulla M
期刊：Nature Genetics影响因子：29.000
时间：2011起止号：2011 Mar;43(3):185-7
doi：10.1038/ng.760方法学： HTRF
研究方向： 肿瘤疾病类型： 乳腺癌

Abstract

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.

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