Establishment of an induced pluripotent stem cell line SPHi001-A from a systemic lupus erythematosus patient combined with preeclampsia and psoriasis

系统性红斑狼疮合并子痫前期及银屑病患者诱导性多能干细胞系SPHi001-A的建立

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作者:Dandan Li, Xiaoping Hong, Weilong Li, Shuhui Meng, Haiyan Yu, Xinzhou Zhang, Cuihua Wang, Igor M Samokhvalov, Dongzhou Liu, Donge Tang, Yong Dai

Abstract

Systemic lupus erythematosus (SLE) is a heterogeneous, autoimmune disease that can affect multiple organs and systems such as skin, joints, kidneys, hematologic system or central nervous system. Women of childbearing age are the predominate population affected by SLE. In this study, we generated an iPS cell line from a 30-year-old female who was pregnant with a gestational age of 27 weeks and diagnosed with severe preeclampsia, SLE and psoriasis. This patient-specific iPSC line will be useful to create the specific disease model of systemic lupus erythematosus to elucidate the pathological mechanisms and develop drug screening.

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