Abstract
OBJECTIVES: Sepsis-associated encephalopathy (SAE) patients in the intensive care unit (ICU) and perioperative period are administrated supplemental oxygen. However, the correlation between oxygenation status with SAE and the target for oxygen therapy remains unclear. This study aimed to examine the relationship between oxygen therapy and SAE patients. METHODS: Patients diagnosed with sepsis 3.0 in the intensive care unit (ICU) were enrolled. The data were collected from the Medical Information Mart for Intensive Care IV (MIMIC IV) database and the eICU Collaborative Research Database (eICU-CRD) database. The generalized additive models were adopted to estimate the oxygen therapy targets in SAE patients. The results were confirmed by multivariate Logistic, propensity score analysis, inversion probability-weighting, doubly robust model, and multivariate COX analyses. Survival was analyzed by the Kaplan-Meier method. RESULTS: A total of 10055 patients from eICU-CRD and 1685 from MIMIC IV were included. The incidence of SAE patients was 58.43%. The range of PaO(2) (97-339) mmHg, PaO(2)/FiO(2) (189-619), and S(P)O(2)≥93% may reduce the incidence of SAE, which were verified by multivariable Logistic regression, propensity score analysis, inversion probability-weighting, and doubly robust model estimation in MIMIC IV database and eICU database. The range of PaO(2)/FiO(2) (189-619) and S(P)O(2)≥93% may reduce the hospital mortality of SAE were verified by multivariable COX regression. CONCLUSIONS: SAE patients in ICU, including perioperative period, require conservative oxygen therapy. We should maintain S(P)O(2)≥93%, PaO(2) (97-339) mmHg and PaO(2)/FiO(2) (189-619) in SAE patients.