Abstract
BACKGROUND: Oxidative stress is a risk factor for the development of low muscle mass. The Composite Dietary Antioxidant Index (CDAI) is a recently developed tool for comprehensively assessing dietary antioxidant exposure. We aimed to explore the association of the CDAI with low muscle mass in the general U.S. METHODS: The participants were individuals aged ≥ 20 years who completed the NHANES from 2001 to 2006 and 2011-2018. The CDAI was assessed by 24-h dietary recall, which integrated the dietary intake levels of vitamin A, vitamin C, vitamin E, zinc, selenium, and carotenoids. Low muscle mass was diagnosed by the Foundation for the National Institutes of Health (FNIH) criteria and defined as an appendicular lean mass/body mass index of < 0.789 in men or < 0.521 in women. Multivariate logistic regression analysis was used to explore the associations of the CDAI and its components with low muscle mass. RESULTS: A total of 15,907 participants were included. The prevalence of low muscle mass was 7.985%. After adjusting for all confounders, the CDAI was found to be significantly associated with the odds of low muscle mass (odds ratio [OR] = 0.928, p < 0.0001). Compared with Q1, the CDAI values at Q2, Q3, and Q4 were significantly associated with a lower prevalence of low muscle mass (p for trend < 0.0001). Higher intake levels of individual CDAI components were associated with a lower prevalence of low muscle mass. Threshold effect analysis revealed that a CDAI ≤ -2.85 was not associated with the odds of low muscle mass (p = 0.1564), while a CDAI > -2.85 was negatively associated with low muscle mass (OR = 0.92, p < 0.0001). Physical activity, smoking, and alcohol consumption significantly moderated this association. CONCLUSIONS: Adherence to an antioxidant diet is associated with low muscle mass among the general U.S. adult population, especially among individuals who maintain a favourable lifestyle. These findings should be further validated in cohort studies.