L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid

L-脯氨酸作为一种高效且可重复使用的促进剂,用于离子液体中香豆素的合成。

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Abstract

The effect of L-proline as a promoter on the condensation reaction of salicylaldehyde or its derivatives with ethyl acetoacetate in neutral ionic liquid [emim]BF4 was studied. All reactions were carried out under mild reaction conditions and achieved high yields. Moreover, the ionic liquid containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity. The results show that the L-proline-[emim]BF4 system has a potential in contribution to the development of environmentally friendly and inexpensive processes in organic syntheses.

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