Abstract
OBJECTIVE: The sliding motion of the liver during respiration violates the homogeneous motion smoothness assumption in conventional non-rigid image registration and commonly results in compromised registration accuracy. This paper presents a novel approach, registration with 3D active contour motion segmentation (RAMS), to improve registration accuracy with discontinuity-aware motion regularization. METHODS: A Markov random field-based discrete optimization with dense displacement sampling and self-similarity context metric is used for registration, while a graph cuts-based 3D active contour approach is applied to segment the sliding interface. In the first registration pass, a mask-free L1 regularization on an image-derived minimum spanning tree is performed to allow motion discontinuity. Based on the motion field estimates, a coarse segmentation finds the motion boundaries. Next, based on MR signal intensity, a fine segmentation aligns the motion boundaries with anatomical boundaries. In the second registration pass, smoothness constraints across the segmented sliding interface are removed by masked regularization on a minimum spanning forest and masked interpolation of the motion field. RESULTS: For in vivo breath-hold abdominal MRI data, the motion masks calculated by RAMS are highly consistent with manual segmentations in terms of Dice similarity and bidirectional local distance measure. These automatically obtained masks are shown to substantially improve registration accuracy for both the proposed discrete registration as well as conventional continuous non-rigid algorithms. CONCLUSION/SIGNIFICANCE: The presented results demonstrated the feasibility of automated segmentation of the respiratory sliding motion interface in liver MR images and the effectiveness of using the derived motion masks to preserve motion discontinuity.