Carbon quantum dot-based fluorometric detection of nitrosamine impurities in active pharmaceutical ingredients

基于碳量子点的荧光法检测活性药物成分中的亚硝胺杂质

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Abstract

Nitrosamines are genotoxic, mutagenic impurities and are widely encountered in the global landscape of the pharmaceutical industry. There is a need for rapid detection of nitrosamines in a pharmaceutical product. Here, we report the synthesis of carbon quantum dots (CQDs) using a readily available carbon precursor. These CQDs showed attractive fluorescence properties and were employed to fabricate a portable device for the fluorometric detection of nitrosamine impurities in a drug matrix.

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