Opposing effects of spinal nerve ligation on calcium-activated potassium currents in axotomized and adjacent mammalian primary afferent neurons

脊神经结扎对轴突切断和邻近哺乳动物初级传入神经元中钙激活钾电流的相反影响

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作者:Constantine D Sarantopoulos, J Bruce McCallum, Marcel Rigaud, Andreas Fuchs, Wai-Meng Kwok, Quinn H Hogan

Conclusions

Axotomy decreases I(K(Ca)) due to a direct effect on K((Ca)) channels. Axotomy-induced loss of I(Ca) may further potentiate current reduction. This reduction in I(K(Ca)) may contribute to elevated excitability after axotomy. Adjacent neurons (L4 after SNL) exhibit increased I(K(Ca)) current.

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