Intestinal Perforation Secondary to Bortezomib-Induced Autonomic Neuropathy

硼替佐米诱发的自主神经病变引起的肠穿孔

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Abstract

It is essential to evaluate both the patient's prior conditions and the severity of the current clinical presentation when deciding on BTZ toxicity management. It seems prudent to consider the permanent discontinuation of the drug in patients who have experienced at least grade 3 intestinal neuropathy and have structural abnormalities or other risk factors for intestinal perforation. Trial Registration: NCT03710603.

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