A complex case of necrobiotic xanthogranuloma with IgG-kappa paraproteinemia: Disease regression achieved with melphalan and prednisone combination therapy

Necrobiotic xanthogranuloma (NXG) is a rare dermatosis that is often associated with monoclonal paraproteinemia and hematological malignancies. We report the rare case of an 84-year-old gentleman with extensive truncal NXG and IgG-kappa paraproteinemia who achieved significant disease regression following six cycles of combination melphalan/prednisone therapy.