Abstract
A bioassay-guided phytochemical study of the fruits of Cornus officinalis led to the isolation of six new iridoid glycoside dimers, named corndiridoside A-F (1-6), along with 11 analogs (7-17). The structure of these dimers was elucidated using HRESIMS, 1D and 2D NMR, IR, and UV spectra, as well as literature comparisons. The anti-inflammatory activity of all compounds was evaluated, revealing a significant inhibitory effect on all dimers on the production of NO in LPS-stimulated RAW 264.7 cells at concentrations of 25 and 50 μM. Of the six, compounds 2 and 3 showed the strongest anti-inflammatory activity.