Abstract
Carbapenem-hydrolyzing β-lactamase (carbapenemase) genes have been disseminated among bacteria worldwide; however, only a few instances of bacterial isolates harboring the carbapenemase gene bla (OXA-48) have been reported in Vietnam. Here we report the first genetic characterization of bla (OXA-48) -harboring Enterobacterales isolates in Vietnam. Three isolates- Enterobacter hormaechei , Klebsiella pneumoniae , and Escherichia coli -were clinically collected in Hanoi between 2010 and 2015. Whole-genome sequencing revealed that these isolates carried bla (OXA-48) on nearly identical IncL plasmids, closely related to globally disseminated pOXA-48a-like plasmids. Our findings highlight the potential spread of highly transmissible bla (OXA-48) -carrying plasmids in Vietnam, emphasizing the importance of continued surveillance.