Generation of an iPSC line (CHWi001-A) from peripheral blood mononuclear cells in a patient with intellectual disability and haploinsufficiency of PLPPR4
从患有智力障碍和 PLPPR4 单倍体不足的患者的外周血单核细胞中生成 iPSC 系 (CHWi001-A)
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作者:Ru Wan, Qian Zhang, Huanzheng Li, Xueqin Xu, Shaohua Tang
| 期刊: | Stem Cell Research | 影响因子: | 0.800 |
| 时间: | 2020 | 起止号: | 2020 May:45:101811. |
| doi: | 10.1016/j.scr.2020.101811 | 研究方向: | 细胞生物学 |
| 细胞类型: | 单核细胞 | |
Abstract
Intellectual disability (ID) is a highly inherited neurodevelopmental disorder. A human induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells (PBMCs) in a patient with intellectual disability and carrying a haploinsufficiency for PLPPR4. This iPSC line offers a useful resource to investigate the pathogenesis and molecular mechanisms involved in PLPPR4-related ID.
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