Abstract
Orf, also known as ecthyma contagiosum, is a highly contagious zoonotic infection linked to direct contact with infected sheep, goats, or reindeer, posing a significant risk to farmers, veterinarians, shepherds, and butchers. This study presents a case of a 41-year-old female who developed Orf, complicated by the rare occurrence of erythema multiforme (EM), after handling sheep meat. The patient initially presented with a progressive, painful skin eruption on the left dorsum of the little finger, which subsequently worsened and led to the development of generalized painful and itchy skin lesions, including target lesions typical of EM, on the palms, soles, and extremities. The diagnosis was confirmed through clinical examination and skin biopsy. The patient was treated with antihistamines and topical corticosteroids, resulting in a complete resolution of symptoms within three weeks. We underscore the importance of recognizing EM as a potential complication of Orf infection, particularly in individuals with occupational animal exposure.