Abstract
OBJECTIVE: To explore the clinical efficacy of percutaneous mechanical thrombectomy (PMT) combined with catheter-directed thrombolysis (CDT) for subacute lower extremity deep vein thrombosis (DVT). METHODS: A retrospective analysis was conducted on 93 patients with subacute lower extremity DVT, divided into the CDT group (n=45) and combined group (PMT + CDT, n=48) by treatment regimen. Clinical efficacy, thrombus clearance, related indicators and safety were compared between the two groups. RESULTS: The total effective rate of the combined group (97.92%) was significantly higher than that of the CDT group (82.22%) (P<0.05), with superior thrombus removal grade, significantly shorter thrombolysis duration, lower drug dosage and shorter hospital stay (all P<0.05). After treatment, the combined group showed more significant improvements in coagulation, inflammation, limb circumference difference and hemorheology indexes, with a lower recurrence rate (4.17% vs 17.78%, P<0.05). There was no significant difference in complication rate between the two groups (P>0.05). CONCLUSION: PMT combined with CDT exerts significant efficacy and favorable safety in treating subacute lower extremity DVT, and can reduce recurrence risk.