False aminoglycoside resistance in Enterobacterales and non-fermenters by an automated testing system: a descriptive study

利用自动化检测系统对肠杆菌科细菌和非发酵菌的氨基糖苷类抗生素耐药性进行假阳性检测:一项描述性研究

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Abstract

Antimicrobial sensitivity data are important to guide antimicrobial therapy. In microbiological laboratories, routine sensitivity measurements are typically performed with automated testing systems such as VITEK2 and Phoenix. Using data from the Dutch national surveillance system for antimicrobial resistance over a 6-year period, we found that the measured minimum inhibitory concentrations for aminoglycosides in Enterobacterales and non-fermenters were too high for the Phoenix system. In addition, we observed a yearly increase in resistance for several species measured by Phoenix. These findings might have consequences for clinical treatment of patients with sepsis.

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