Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

COVID-19 大流行对脑静脉血栓形成和死亡率的全球影响

阅读：1
作者：Nguyen,Thanh N,Qureshi,Muhammad M,Klein,Piers,Yamagami,Hiroshi,Abdalkader,Mohamad,Mikulik,Robert,Sathya,Anvitha,Mansour,Ossama Yassin,Czlonkowska,Anna,Lo,Hannah,Field,Thalia S,Charidimou,Andreas,Banerjee,Soma,Yaghi,Shadi,Siegler,James E,Sedova,Petra,Kwan,Joseph,de Sousa,Diana Aguiar,Demeestere,Jelle,Inoa,Violiza,Omran,Setareh Salehi,Zhang,Liqun,Michel,Patrik,Strambo,Davide,Marto,João Pedro,Nogueira,Raul G,Kristoffersen,Espen Saxhaug,Tsivgoulis,Georgios,Lereis,Virginia Pujol,Ma,Alice,Enzinger,Christian,Gattringer,Thomas,Rahman,Aminur,Bonnet,Thomas,Ligot,Noémie,De Raedt,Sylvie,Lemmens,Robin,Vanacker,Peter,Vandervorst,Fenne,Conforto,Adriana Bastos,Hidalgo,Raquel C T,Mora Cuervo,Daissy Liliana,de Oliveira Neves,Luciana,Lameirinhas da Silva,Isabelle,Martíns,Rodrigo Targa,Rebello,Letícia C,Santiago,Igor Bessa,Sakelarova,Teodora,Kalpachki,Rosen,Alexiev,Filip,Cora,Elena Adela,Kelly,Michael E,Peeling,Lissa,Pikula,Aleksandra,Chen,Hui-Sheng,Chen,Yimin,Yang,Shuiquan,Roje Bedekovic,Marina,Čabal,Martin,Tenora,Dusan,Fibrich,Petr,Dušek,Pavel,Hlaváčová,Helena,Hrabanovska,Emanuela,Jurák,Lubomír,Kadlčíková,Jana,Karpowicz,Igor,Klečka,Lukáš,Kovář,Martin,Neumann,Jiří,Paloušková,Hana,Reiser,Martin,Rohan,Vladimir,Šimůnek,Libor,Skoda,Ondreij,Škorňa,Miroslav,Šrámek,Martin,Drenck,Nicolas,Sobh,Khalid,Lesaine,Emilie,Sabben,Candice,Reiner,Peggy,Rouanet,Francois,Strbian,Daniel,Boskamp,Stefan,Mbroh,Joshua,Nagel,Simon,Rosenkranz,Michael,Poli,Sven,Thomalla,Götz,Karapanayiotides,Theodoros,Koutroulou,Ioanna,Kargiotis,Odysseas,Palaiodimou,Lina,Barrientos Guerra,José Dominguo,Huded,Vikram,Nagendra,Shashank,Prajapati,Chintan,Sylaja,P N,Sani,Achmad Firdaus,Ghoreishi,Abdoreza,Farhoudi,Mehdi,Sadeghi Hokmabadi,Elyar,Hashemilar,Mazyar,Sabetay,Sergiu Ionut,Rahal,Fadi,Acampa,Maurizio,Adami,Alessandro,Longoni,Marco,Ornello,Raffaele,Renieri,Leonardo,Romoli,Michele,Sacco,Simona,Salmaggi,Andrea,Sangalli,Davide,Zini,Andrea,Sakai,Kenichiro,Fukuda,Hiroki,Fujita,Kyohei,Imamura,Hirotoshi,Kosuke,Miyake,Sakaguchi,Manabu,Sonoda,Kazutaka,Matsumaru,Yuji,Ohara,Nobuyuki,Shindo,Seigo,Takenobu,Yohei,Yoshimoto,Takeshi,Toyoda,Kazunori,Uwatoko,Takeshi,Sakai,Nobuyuki,Yamamoto,Nobuaki,Yamamoto,Ryoo,Yazawa,Yukako,Sugiura,Yuri,Baek,Jang-Hyun,Lee,Si Baek,Seo,Kwon-Duk,Sohn,Sung-Il,Lee,Jin Soo,Arsovska,Anita Ante,Chieh,Chan Yong,Wan Zaidi,Wan Asyraf,Wan Yahya,Wan Nur Nafisah,Gongora-Rivera,Fernando,Martinez-Marino,Manuel,Infante-Valenzuela,Adrian,Dippel,Diederik,van Dam-Nolen,Dianne H K,Wu,Teddy Y,Punter,Martin,Adebayo,Tajudeen Temitayo,Bello,Abiodun H,Sunmonu,Taofiki Ajao,Wahab,Kolawole Wasiu,Sundseth,Antje,Al Hashmi,Amal M,Ahmad,Saima,Rashid,Umair,Rodriguez-Kadota,Liliana,Vences,Miguel Ángel,Yalung,Patrick Matic,Dy,Jon Stewart Hao,Brola,Waldemar,Dębiec,Aleksander,Dorobek,Malgorzata,Karlinski,Michal Adam,Labuz-Roszak,Beata M,Lasek-Bal,Anetta,Sienkiewicz-Jarosz,Halina,Staszewski,Jacek,Sobolewski,Piotr,Wiącek,Marcin,Zielinska-Turek,Justyna,Araújo,André Pinho,Rocha,Mariana,Castro,Pedro,Ferreira,Patricia,Nunes,Ana Paiva,Fonseca,Luísa,Pinho E Melo,Teresa,Rodrigues,Miguel,Silva,M Luis,Ciopleias,Bogdan,Dimitriade,Adela,Falup-Pecurariu,Cristian,Hamid,May Adel,Venketasubramanian,Narayanaswamy,Krastev,Georgi,Haring,Jozef,Ayo-Martin,Oscar,Hernandez-Fernandez,Francisco,Blasco,Jordi,Rodríguez-Vázquez,Alejandro,Cruz-Culebras,Antonio,Moniche,Francisco,Montaner,Joan,Perez-Sanchez,Soledad,García Sánchez,María Jesús,Guillán Rodríguez,Marta,Bernava,Gianmarco,Bolognese,Manuel,Carrera,Emmanuel,Churojana,Anchalee,Aykac,Ozlem,Özdemir,Atilla Özcan,Bajrami,Arsida,Senadim,Songul,Hussain,Syed I,John,Seby,Krishnan,Kailash,Lenthall,Robert,Asif,Kaiz S,Below,Kristine,Biller,Jose,Chen,Michael,Chebl,Alex,Colasurdo,Marco,Czap,Alexandra,de Havenon,Adam H,Dharmadhikari,Sushrut,Eskey,Clifford J,Farooqui,Mudassir,Feske,Steven K,Goyal,Nitin,Grimmett,Kasey B,Guzik,Amy K,Haussen,Diogo C,Hovingh,Majesta,Jillela,Dinesh,Kan,Peter T,Khatri,Rakesh,Khoury,Naim N,Kiley,Nicole L,Kolikonda,Murali K,Lara,Stephanie,Li,Grace,Linfante,Italo,Loochtan,Aaron I,Lopez,Carlos D,Lycan,Sarah,Male,Shailesh S,Nahab,Fadi,Maali,Laith,Masoud,Hesham E,Min,Jiangyong,Orgeta-Gutierrez,Santiago,Mohamed,Ghada A,Mohammaden,Mahmoud,Nalleballe,Krishna,Radaideh,Yazan,Ramakrishnan,Pankajavalli,Rayo-Taranto,Bliss,Rojas-Soto,Diana M,Ruland,Sean,Simpkins,Alexis N,Sheth,Sunil A,Starosciak,Amy K,Tarlov,Nicholas E,Taylor,Robert A,Voetsch,Barbara,Zhang,Linda,Duong,Hai Quang,Dao,Viet-Phuong,Le,Huynh Vu,Pham,Thong Nhu,Ton,Mai Duy,Tran,Anh Duc,Zaidat,Osama O,Machi,Paolo,Dirren,Elisabeth,Rodríguez Fernández,Claudio,Escartín López,Jorge,Fernández Ferro,Jose Carlos,Mohammadzadeh,Niloofar,Suryadevara,Neil C,de la Cruz Fernández,Beatriz,Bessa,Filipe,Jancar,Nina,Brady,Megan,Scozzari,Dawn
期刊：Journal of Stroke影响因子：8.600
时间：2022起止号：2022 May;24(2):256-265
doi：10.5853/jos.2022.00752

Abstract

BACKGROUND AND PURPOSE: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. METHODS: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). RESULTS: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. CONCLUSIONS: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。