Abstract
Thrombosis is a leading cause of cardiovascular diseases, driven by platelet aggregation, endothelial activation, and vascular occlusion. While Allium cepa L. (onion) is known for its health benefits, the antithrombotic potential of its peel remains underexplored. This study investigates the effects of Allium cepa L. peel extract (APE) in a rat model of collagen and epinephrine (CE)-induced thrombosis. High-performance liquid chromatography confirmed that APE contains high levels of quercetin, a flavonoid with known vascular protective properties. Animal experiments showed that APE significantly prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), indicating decreased hypercoagulability. Furthermore, APE suppressed genetic expression of key adhesion molecules (ICAM-1, VCAM-1, P-selectin, and E-selectin) in aortic tissue, suggesting reduced endothelial activation. Histological analysis also demonstrated a decrease in pulmonary vascular occlusion. These results suggest that APE may help prevent thrombosis by regulating coagulation and protecting endothelial function, supporting its potential as a natural antithrombotic agent.