Abstract
The development of non-cirrhotic portal hypertension and esophagogastric varices is an uncommon, yet life-threatening complication of splenic vein thrombosis. Recognizing this association between splenic vein thrombosis and non-cirrhotic portal hypertension is critical in reducing morbidity and mortality in patients with hypercoagulable disease secondary to malignancy. Herein, we present a 45-year-old female with stage IV high-grade serous ovarian carcinoma and chronic splenic vein thrombosis found to have life-threatening esophagogastric varices secondary to non-cirrhotic portal hypertension.