Abstract
Ten previously undescribed compounds, including eight lanostane-meroterpene conjugates, ganohochimins A-H (1-8), a lanostane dimer, ganohochimate A (9), and a meroterpenoid, fornicin F (10), were isolated from the cultivated mushroom Ganoderma cf. hochiminhense-(strain TBRC-BCC 22084). The 24S-configuration of ganohochimin A (1) was determined by cleavage of the aryl ether under acidic conditions. The structure of ganohochimate A (9) was confirmed by alkaline hydrolysis to cleave into two lanostane units. Ganohochimins exhibited cytotoxicity against NCI-H187 (small-cell lung cancer) cells (IC(50) 7.7-33 μM) and noncancerous Vero cells (IC(50) 6.3-30 μM).