Abstract
In predictive coding (PC), higher-order brain areas generate predictions that are sent to lower-order sensory areas. Top-down predictions are compared with bottom-up sensory data, and mismatches evoke prediction errors. In PC, the prediction errors are encoded in layer 2/3 pyramidal neurons of sensory cortex that feed forward. The PC model has been tested with multiple recording modalities using the global-local oddball paradigm. Consistent with PC, neuroimaging studies reported prediction error responses in sensory and higher-order areas. However, recent studies of neuronal spiking suggest that genuine prediction errors emerge in prefrontal cortex (PFC). This implies that predictive processing is a more cognitive than sensory-based mechanism - an observation that challenges PC and better aligns with a framework we call predictive routing (PR).